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. 2011 Nov;52(3):215-21.
doi: 10.1016/j.jcv.2011.07.017. Epub 2011 Aug 30.

Disease burden of the most commonly detected respiratory viruses in hospitalized patients calculated using the disability adjusted life year (DALY) model

E R Gaunt  1 , H Harvala, C McIntyre, K E Templeton, P Simmonds
Affiliations

Disease burden of the most commonly detected respiratory viruses in hospitalized patients calculated using the disability adjusted life year (DALY) model

E R Gaunt et al. J Clin Virol. 2011 Nov.

Abstract

Background: The most common acute infections occur in the respiratory tract. Recent discoveries of several novel viruses have markedly increased the repertoire of agents understood to cause presentations of acute respiratory disease.

Objectives: Further understanding is needed of the relative importance of newly discovered pathogens in the clinical setting to provide clinicians with an indication of appropriate diagnostic and therapeutic targets. To address this, quantification of the disease burden of respiratory viruses in hospitalized patients was undertaken.

Study design: Disease burden caused by respiratory viruses in hospitalized patients was quantified using the World Health Organization endorsed DALY model. Diagnostic testing results from samples collected over three years for adenovirus (AdV), influenzas A and B, parainfluenza viruses 1, 2 and 3 (PIV-1, -2 and -3), respiratory syncytial virus (HRSV), and previously published retrospective screening for human metapneumovirus, rhinoviruses, and four respiratory coronaviruses were applied to the DALY model. Disability weights were calculated per 1000 hospitalized patients in age banded groups.

Results: Strikingly different disease burden profiles were observed in children and adults. Adenoviruses were among the leading cause of respiratory presentations in children but not adults. HRSV and influenza A were consistently one of the greatest causes of disease regardless of sampled population. Rhinoviruses and PIV-3 were significant pathogens in all groups except those aged 16-64 years. In immunocompromised patients rhinoviruses were the leading viral cause of disease.

Conclusions: These analyses provide a framework which can be used to identify where finite resources should be directed in respiratory therapeutics and vaccine development.

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Figures

Fig. 1
Fig. 1
Clinical presentations associated with the most commonly detected respiratory viruses. AdV, adenovirus; Flu, influenza; PIV, parainfluenza virus; HRSV, human respiratory syncytial virus; HCoVs, human coronaviruses; HRV, human rhinovirus.
Fig. 2
Fig. 2
Relative proportion of disease burden caused by the most commonly detected respiratory viruses by age group. AdV, adenovirus; Flu, influenza; PIV, parainfluenza virus; HRSV, human respiratory syncytial virus; HCoVs, human coronaviruses; HRV, human rhinovirus.
Fig. 3
Fig. 3
Relative disease burden caused by the most commonly detected respiratory viruses in males compared with females. AdV, adenovirus; Flu, influenza; PIV, parainfluenza virus; HRSV, human respiratory syncytial virus; HCoVs, human coronaviruses; HRV, human rhinovirus.
See this image and copyright information in PMC

References

    1. World Health Organization . 2001. World health report.
    1. van den Hoogen B.G., de Jong J.C., Groen J., Kuiken T., de Groot R., Fouchier R.A.M. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7:719–724. - PMC - PubMed
    1. van der Hoek L., Pyrc K., Jebbink M.F., Vermeulen-Oost W., Berkhout R.J., Wolthers K.C. Identification of a new human coronavirus. Nat Med. 2004;10(4):368–373. - PMC - PubMed
    1. Woo P.C.Y., Lau S.K.P., Chu C.M., Chan K.H., Tsoi H.W., Huang Y. Characterization and complete genome sequence of a novel coronavirus: coronavirus HKU1, from patients with pneumonia. J Virol. 2005;79(2):884–895. - PMC - PubMed
    1. Lau S.K.P., Yip C.C.Y., Tsoi H.W., Lee R.A., So L.Y., Lau Y.L. Clinical features and complete genome characterization of a distinct human rhinovirus genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children. J Clin Microbiol. 2007 p. JCM. 01254-07. - PMC - PubMed

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