The miR-10 microRNA precursor family

Abstract

The miR-10 microRNA precursor family encodes a group of short non-coding RNAs involved in gene regulation. The miR-10 family is highly conserved and has sparked the interest of many research groups because of the genomic localization in the vicinity of, coexpression with and regulation of the Hox gene developmental regulators. Here, we review the current knowledge of the evolution, physiological function and involvement in cancer of this family of microRNAs.

Figure 1

Hox gene cluster organization and position of miR-10/100 family members. Selected organisms from the bilaterian clade are shown: human, zebrafish, fly (Drosophila melanogaster) and worm (Caenorhabditis elegans). Each box denotes a Hox- or Hox-related gene. Horizontal lines represent individual chromosomes. The position of miR-10/100 family members within Hox clusters are indicated in red and those that are encoded outside are listed below.

Figure 2

Conservation of miR-100/10 family members. (A) Alignment of selected human, zebrafish (dre), fly (dme), nematode (cel) and sea anemone (nve) miR-100/10 family members. (B) Alignment of the human miR-10/100 paralogues. Predominant mature miRNA sequences are highlighted in black. Conservation is marked by *. The stem-loop structure of the top miRNA is shown above in bracket annotation, where each pair of parenthesis denotes a base pair. miRNA annotation and secondary structures are from miRBase v16. (C) Conserved secondary structure of miR-10. The mature miRNA and miRNA* sequence including seeds are indicated. Base nomenclature: B(G/C/T), H(A/T/C), K(G/T), M(A/C), R(A/G), S(G/C), V(G/A/C), W(A/T), Y (T/C), (From en.wikipedia.org/wiki/Mir-10_microRNA_precursor_family).