[100 years of lectin research--a balance]
- PMID: 2188142
- DOI: 10.1007/BF01134469
[100 years of lectin research--a balance]
Abstract
A hundred years of lectin research has led to the development of lectinology as an independent field of study. Although lectinology is in part related to immunology, fundamental differences exist. Lectins are important tools in biochemistry, histochemistry and clinical diagnosis. The essential in vivo function of lectins is to combine glycoconjugates. The function of lectins in microorganisms and in animals is partially known, whereas the function of lectins in plants is mostly unclear. Of special interest, now as before, are the toxic lectins of the ricin type consisting of an A-chain (N-glycosidase) and a B-chain (D-galactose-specific lectin).
Similar articles
-
Double-lectin site ricin B chain mutants expressed in insect cells have residual galactose binding: evidence for more than two lectin sites on the ricin toxin B chain.Bioconjug Chem. 1996 Nov-Dec;7(6):651-8. doi: 10.1021/bc960056b. Bioconjug Chem. 1996. PMID: 8950484
-
Comparison of properties of mistletoe lectin I A-chain and ricin B-chain conjugate with native toxins.FEBS Lett. 1993 Dec 20;336(1):100-2. doi: 10.1016/0014-5793(93)81618-a. FEBS Lett. 1993. PMID: 8262189
-
The sugar-combining area of the galactose-specific toxic lectin of mistletoe extends beyond the terminal sugar residue: comparison with a homologous toxic lectin, ricin.Carbohydr Res. 1994 Feb 17;254:269-76. doi: 10.1016/0008-6215(94)84259-0. Carbohydr Res. 1994. PMID: 8180989
-
Reverse lectin histochemistry: design and application of glycoligands for detection of cell and tissue lectins.Histol Histopathol. 1993 Apr;8(2):369-83. Histol Histopathol. 1993. PMID: 8490266 Review.
-
Cytotoxic ribosome-inactivating lectins from plants.Biochim Biophys Acta. 2004 Sep 1;1701(1-2):1-14. doi: 10.1016/j.bbapap.2004.06.004. Biochim Biophys Acta. 2004. PMID: 15450171 Review.
Cited by
-
Histochemical response of mice to mistletoe lectin I (ML I).Histochemistry. 1990;94(5):531-7. doi: 10.1007/BF00272618. Histochemistry. 1990. PMID: 2283317
-
[Tumor lectinology--status and perspectives of clinical application].Naturwissenschaften. 1990 Nov;77(11):505-14. doi: 10.1007/BF01139261. Naturwissenschaften. 1990. PMID: 2074894 Review. German.
-
A lectin from the liverwort Marchantia polymorpha L.Experientia. 1993 Dec 15;49(12):1098-100. doi: 10.1007/BF01929921. Experientia. 1993. PMID: 8270033