[The significance of HbA1 determination in children]

Abstract

The determination of glycated haemoglobin permits a good evaluation of metabolic regulation of diabetics. The development of vascular complications depends on duration and degree of hyperglycemia. It is presented the different chemical reactions of glucose with proteins in diabetes. The consequences are structural and functional changes of a variety of human proteins. This is a part of long-term complications of diabetics. Collagen is used as an example for a protein with a relatively slow turnover rate that could allow for an accumulation of altered protein.