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. 2011 Nov;176(5):688-91.
doi: 10.1667/rr2704.1. Epub 2011 Sep 1.

Decreasing the adverse effects of cancer therapy: an NCI Workshop on the preclinical development of radiation injury mitigators/protectors

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Decreasing the adverse effects of cancer therapy: an NCI Workshop on the preclinical development of radiation injury mitigators/protectors

Julie L Ryan et al. Radiat Res. 2011 Nov.
No abstract available

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Figure 1
Figure 1. Pathway for preclinical evaluation of novel agents
This schematic outlines the preclinical data required for novel radiation mitigators/protectors for implementation in clinical trials. A novel candidate agent should satisfy at least one of the final selection criteria to be considered for preclinical testing and evaluation.

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References

    1. Stone HB, Moulder JE, Coleman CN, Ang KK, Anscher MS, Barcellos-Hoff MH, Dynan WS, Fike JR, Grdina DJ, Greenberger JS, Hauer-Jensen M, Hill RP, Kolesnick RN, Macvittie TJ, Marks C, McBride WH, Metting N, Pellmar T, Purucker M, Robbins ME, Schiestl RH, Seed TM, Tomaszewski JE, Travis EL, Wallner PE, Wolpert M, Zaharevitz D. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3–4, 2003. Radiat Res. 2004 Dec;162(6):711–28. - PubMed
    1. Patt HM, Mayer SH, Straube RL, Jackson EM. Radiation dose reduction by cysteine. J Cell Physiol. 1953 Dec;42(3):327–41. - PubMed
    1. Cassatt DR, Kaminski JM, Hatchett RJ, DiCarlo AL, Benjamin JM, Maidment BW. Medical countermeasures against nuclear threats: radionuclide decorporation agents. Radiat Res. 2008 Oct;170(4):540–8. - PMC - PubMed
    1. DiCarlo AL, Hatchett RJ, Kaminski JM, Ledney GD, Pellmar TC, Okunieff P, Ramakrishnan N. Medical countermeasures for radiation combined injury: radiation with burn, blast, trauma and/or sepsis. report of an NIAID Workshop, March 26–27, 2007. Radiat Res. 2008 Jun;169(6):712–21. - PMC - PubMed
    1. Dumont F, Le Roux A, Bischoff P. Radiation countermeasure agents: an update. Expert Opin Ther Pat. 2010 Jan;20(1):73–101. - PubMed

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