Comment
doi: 10.1016/j.cell.2011.08.019.
A new FOXO pathway required for leukemogenesis
Affiliations
- PMID: 21884926
- DOI: 10.1016/j.cell.2011.08.019
Item in Clipboard
Comment
A new FOXO pathway required for leukemogenesis
Cell.
.
Free article
Abstract
In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly inactivated by oncogenic signaling through the PI3K/AKT pathway. Now, Skykes et al. (2011) identify a paradoxical requirement for FOXOs in the maintenance of leukemia-initiating cells.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
-
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.Cell. 2011 Sep 2;146(5):697-708. doi: 10.1016/j.cell.2011.07.032. Cell. 2011. PMID: 21884932 Free PMC article.
Publication types
LinkOut - more resources
Full Text Sources
