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Comment
. 2011 Sep 2;146(5):673-4.
doi: 10.1016/j.cell.2011.08.018.

When T cells run out of breath: the HIF-1α story

Katherine Nutsch  1 , Chyi Hsieh
Affiliations
Free article
Comment

When T cells run out of breath: the HIF-1α story

Katherine Nutsch et al. Cell. .
Free article

Abstract

In this issue, Dang et al. (2011) report a role for the hypoxia-induced transcription factor HIF-1α in regulating the differentiation of T cell subsets that impact both inflammation and its resolution. Their findings illustrate how metabolic signals can alter the balance between inflammation and tolerance and present a potential therapeutic opportunity for the treatment of diseases associated with chronic inflammation.

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  • Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
    Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM, Pan F. Dang EV, et al. Cell. 2011 Sep 2;146(5):772-84. doi: 10.1016/j.cell.2011.07.033. Epub 2011 Aug 25. Cell. 2011. PMID: 21871655 Free PMC article.

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