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Comment
. 2011 Sep 2;43(5):695-7.
doi: 10.1016/j.molcel.2011.08.015.

A new twist on clock protein phosphorylation: a conformational change leads to protein degradation

Jerome S Menet  1 , Michael Rosbash
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A new twist on clock protein phosphorylation: a conformational change leads to protein degradation

Jerome S Menet et al. Mol Cell. .
Free article

Abstract

Progressive phosphorylation of circadian clock proteins is a hallmark of time-keeping. In this issue of Molecular Cell, Querfurth et al. (2011) demonstrate that phosphorylation of Neurospora FRQ induces a conformational change, which can account for its temporally gated degradation.

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