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Comment
. 2011 Sep 2;43(5):697-8.
doi: 10.1016/j.molcel.2011.08.012.

HDAC3 at the fulcrum of an epithelial-mesenchymal balance

Sendurai A Mani  1 , Michelle Craig Barton
Affiliations
Comment

HDAC3 at the fulcrum of an epithelial-mesenchymal balance

Sendurai A Mani et al. Mol Cell. .

Abstract

In this issue of Molecular Cell, Wu et al. (2011) reveal an essential role for a chromatin modifier, histone deacetylase 3 (HDAC3), in hypoxia-induced epithelial-mesenchymal transition (EMT); HIF-activated HDAC3 integrates with WDR5 to impose chromatin modifications that culminate in EMT.

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Figures

Figure 1
Figure 1
Hypoxia tips the epithelial-mesenchymal balance via HDAC3. Both epithelial and mesenchymal cells respond to low levels of oxygen with HIF-dependent induction of HDAC3. In epithelia, increased HDAC3 deacetylates H3K4ac to repress chromatin structure and expression of epithelial genes. In parallel, WDR5 and HDAC3 levels coordinately increase in mesenchymal cells. In these cells, HDAC3 interacts with WDR5; the complex is targeted by Twist to silent mesenchymal genes in order to activate expression (not shown). This combination of events culminates in EMT, and is associated with migration, invasion and a metastatic phenotype.
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References

    1. Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW. Mol Cell. 2008;30:61–72. - PMC - PubMed
    1. Haase VH. Kidney Int. 2009;76:482–489. - PMC - PubMed
    1. Haberland M, Montgomery RL, Olson EN. Nat Rev Genet. 2009;10:32–42. - PMC - PubMed
    1. Hennessy BT, Gonzalez-Angulo AM, Stemke-Hale K, Gilcrease MZ, Krishnamurthy S, Lee JS, Fridlyand J, Sahin A, Agarwal R, Joy C, Liu W, Stivers D, Baggerly K, Carey M, Lluch A, Monteagudo C, He X, Weigman V, Fan C, Palazzo J, Hortobagyi GN, Nolden LK, Wang NJ, Valero V, Gray JW, Perou CM, Mills GB. Cancer Res. 2009;69:4116–4124. - PMC - PubMed
    1. Kalluri R, Neilson EG. J Clin Invest. 2003;112:1776–1784. - PMC - PubMed

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