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Review
. 2011 Sep 2;9(3):187-92.
doi: 10.1016/j.stem.2011.08.005.

Breaking the cell cycle of HSCs by p57 and friends

Melania Tesio  1 , Andreas Trumpp
Affiliations
Free article
Review

Breaking the cell cycle of HSCs by p57 and friends

Melania Tesio et al. Cell Stem Cell. .
Free article

Abstract

The cell cycle regulators involved in maintaining the quiescence, and thereby the self-renewal capacity, of somatic stem cells have long been elusive. Two new Cell Stem Cell articles in this issue (Matsumoto et al., 2011; Zou et al., 2011) now show that the CDK inhibitor p57 is a crucial brake for cycling HSCs, and links self-renewal activity to cell cycle quiescence.

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