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Review
. 1990;10(1):10-20.
doi: 10.1159/000168048.

Solvent nephrotoxicity in humans and experimental animals

N A Nelson  1 , T G Robins, F K Port
Affiliations
Review

Solvent nephrotoxicity in humans and experimental animals

N A Nelson et al. Am J Nephrol. 1990.

Abstract

Evidence from human case reports, epidemiologic studies and animal experiments have suggested that exposure to organic solvents is associated with a wide spectrum of renal disorders, including tubular necrosis, interstitial disease, glomerulonephritis and neoplasia. This review summarizes what is known about solvent-induced renal damage in humans and experimental animals, with emphasis on hypothesized mechanisms by which this broad range of disorders may occur.

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