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. 2011 Oct;45(2):119-23.
doi: 10.1016/j.transci.2011.07.002. Epub 2011 Aug 31.

Thrombotic microangiopathy

M Mörtzell  1 , G Berlin, T Nilsson, C G Axelsson, M Efvergren, J Audzijoni, A Griskevicius, J Ptak, M Blaha, H Tomsova, G M Liumbruno, P Centoni, E Newman, S Eloot, A Dhondt, J Tomaz, V Witt, G Rock, B Stegmayr
Affiliations

Thrombotic microangiopathy

M Mörtzell et al. Transfus Apher Sci. 2011 Oct.

Abstract

Thrombotic microangiopathy (TMA) is a histopathological feature of various diseases including thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). There are many secondary causes of TMA, many of them could mimic TTP or HUS. This article presents a short overview on TMA. In conclusion TMA is the result of various etiology reasons and pathologic reactions with various clinical entities. It is important to focus on a thorough history including family history when deciding on a diagnosis. Analysis of ADAMTS 13 and ADAMTS 13-antibodies may help to decide continued therapy.

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