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Comment
. 2011 Aug 31;3(98):98ps37.
doi: 10.1126/scitranslmed.3003001.

Understanding the enemy

Victor E Velculescu  1 , Luis A Diaz Jr
Affiliations
Comment

Understanding the enemy

Victor E Velculescu et al. Sci Transl Med. .

Abstract

In this issue of Science Translational Medicine, Tanas and colleagues describe a disease-defining genetic alteration for the vascular cancer epithelioid hemangioendothelioma (EHE). The resulting EHE-associated fusion gene encodes an aberrantly expressed putative transcription factor. This molecular information is the latest in a series of genetic discoveries that aid in cancer diagnosis and may pave the way to targeted therapeutic agents.

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Figures

Fig. 1
Fig. 1. Combating cancer
Approaches for translating cancer-genome analyses to patient care.
See this image and copyright information in PMC

Comment on

  • Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma.
    Tanas MR, Sboner A, Oliveira AM, Erickson-Johnson MR, Hespelt J, Hanwright PJ, Flanagan J, Luo Y, Fenwick K, Natrajan R, Mitsopoulos C, Zvelebil M, Hoch BL, Weiss SW, Debiec-Rychter M, Sciot R, West RB, Lazar AJ, Ashworth A, Reis-Filho JS, Lord CJ, Gerstein MB, Rubin MA, Rubin BP. Tanas MR, et al. Sci Transl Med. 2011 Aug 31;3(98):98ra82. doi: 10.1126/scitranslmed.3002409. Sci Transl Med. 2011. PMID: 21885404

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