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Meta-Analysis
. 2012 Feb;33(2):376-81.
doi: 10.3174/ajnr.A2618. Epub 2011 Sep 1.

The association between the duration of preoperative pain and pain improvement in vertebral augmentation: a meta-analysis

A Ehteshami Rad  1 , M T Luetmer, M H Murad, D F Kallmes
Affiliations
Meta-Analysis

The association between the duration of preoperative pain and pain improvement in vertebral augmentation: a meta-analysis

A Ehteshami Rad et al. AJNR Am J Neuroradiol. 2012 Feb.

Abstract

Background and purpose: Most physicians consider length of preoperative pain as an important factor to include patients for SA. Our aim was to synthesize the available evidence regarding the influence of preprocedural pain duration on the outcome of vertebral augmentation procedures.

Materials and methods: The MEDLINE data base was reviewed up to March 2010. Meta-regression and mixed-effect subgroup analyses were performed to evaluate the association between the outcome of interest, which was pain improvement assessed by a VAS (0-10) and the duration of preoperative pain (independent variable).

Results: We included 17 articles. The mean VAS improvements for subgroups of ≤6 weeks (n = 12), 6-24 weeks (n = 5), and >24 weeks (n = 3) were 5.18, 4.90, and 5.04, respectively (P = .86). The regression coefficient was -0.024, suggesting trivial association of the duration of preoperative pain and pain improvement.

Conclusions: Pain relief following spine augmentation was similar among groups of patients with varying lengths of preoperative pain duration.

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Figures

Fig 1.
Fig 1.
Inclusion of the final 17 articles.
Fig 2.
Fig 2.
The forest plot shows subgroup analysis.
Fig 3.
Fig 3.
The linear correlation between preoperative pain duration and pain improvement is shown.
Fig 4.
Fig 4.
Publication bias among studies is shown.
Fig 5.
Fig 5.
The cumulative meta-analysis shows the influence of increasing preoperative pain duration on the outcome of the study.
Fig 6.
Fig 6.
The cumulative meta-analysis shows the influence of increasing sample size on the outcome of the study.
See this image and copyright information in PMC

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