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. 2011 Mar;9(1):151-4.
doi: 10.2174/157015911795017119.

Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese

T Okochi  1 , T Kishi, M Ikeda, T Kitajima, Y Kinoshita, K Kawashima, T Okumura, T Tsunoka, Y Fukuo, T Inada, M Yamada, N Uchimura, M Iyo, I Sora, N Ozaki, H Ujike, N Iwata
Affiliations

Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese

T Okochi et al. Curr Neuropharmacol. 2011 Mar.

Abstract

Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.

Keywords: Methamphetamine-induced psychosis; endothelial nitric oxide synthase (NOS3); gene-based case-control association study..

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