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Case Reports
. 2009 Apr 5;3(1):8-10.
doi: 10.3315/jdcr.2009.1023.

Chronic venous ulceration with associated angiosarcoma

Mohammad Al-Enezi  1 , Alain Brassard
Affiliations
Case Reports

Chronic venous ulceration with associated angiosarcoma

Mohammad Al-Enezi et al. J Dermatol Case Rep. .

Abstract

Background: Angiosarcoma is a malignant tumor of the blood vessels' endothelial lining. The tumor is very aggressive and tends to recur locally and metastasize to distant organs. Commonly, it is associated with different risk factors like lymphoedema, prior radiotherapy but rarely, it may also be associated with chronic venous ulceration.

Main observation: We present a patient with a chronic venous ulceration who developed angiosarcoma of the ulcerated leg with good outcome after treatment.

Conclusion: It is very important to follow patients with chronic wounds and recognize changes which may be life threatening. In addition to squamous cell carcinoma (Marjolin's tumor), which is most common, angiosarcoma can develop within a venous ulcer.

Keywords: CD31; Ulex europaeus; angiosarcoma; pathology; skin; ulcer.

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Figures

Figure 1
Figure 1
Red infiltrative plaques around the left leg medial malleolus ulcer extending proximally and distally.
Figure 2
Figure 2
Infiltrative pleomorphic cells in between collagen bundles, forming spaces. H&E x5 (A) The cells stained positive with endothelial markers. Ulex europaeus x20 (B).
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