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Review
. 2011 Sep;38(3):385-406.
doi: 10.1016/j.clp.2011.06.003. Epub 2011 Jul 20.

The role of inflammation and infection in preterm birth

Jamie A Bastek  1 , Luis M Gómez, Michal A Elovitz
Affiliations
Review

The role of inflammation and infection in preterm birth

Jamie A Bastek et al. Clin Perinatol. 2011 Sep.

Abstract

Much emphasis in recent decades has been devoted to inflammation and infection as a premier causal mechanism of preterm birth. This article explores the epidemiologic, clinical, and animal data that exist to support this conceptual paradigm as well as proposed mechanisms through which to potentially mitigate the adversity of prematurity. Truly successful interventions are not likely to occur until the pathogenesis of preterm birth and the role of inflammation in causing not only parturition but also fetal and neonatal injury is fully elucidated.

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