Comment
doi: 10.1038/ncb2333.
Wnt: what's needed to maintain pluripotency?
- PMID: 21892143
- DOI: 10.1038/ncb2333
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Comment
Wnt: what's needed to maintain pluripotency?
Nat Cell Biol.
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Abstract
A precise role for the canonical Wnt pathway in maintaining pluripotency in mouse embryonic stem cells (mESCs) has been debated. Four recent reports add pieces to the puzzle and together these results may help establish a robust model.
Comment on
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Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation.Nat Cell Biol. 2011 Jun 19;13(7):838-45. doi: 10.1038/ncb2267. Nat Cell Biol. 2011. PMID: 21685889 Free PMC article.
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Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation.Nat Cell Biol. 2011 Jun 19;13(7):753-61. doi: 10.1038/ncb2260. Nat Cell Biol. 2011. PMID: 21685890 Free PMC article.
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Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal.Nat Cell Biol. 2011 Jun 19;13(7):762-70. doi: 10.1038/ncb2283. Nat Cell Biol. 2011. PMID: 21685894 Free PMC article.
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Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells.Nat Cell Biol. 2011 Aug 14;13(9):1070-5. doi: 10.1038/ncb2314. Nat Cell Biol. 2011. PMID: 21841791 Free PMC article.
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