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Comment
. 2011 Sep 2;13(9):1026-7.
doi: 10.1038/ncb2334.

Coupling mitochondrial and cell division

Koji Yamano, Richard J Youle
Comment

Coupling mitochondrial and cell division

Koji Yamano et al. Nat Cell Biol. .

Abstract

The mitochondrial network fragments during mitosis to allow proper segregation of the organelles between daughter cells. Two mitotic kinases, the cyclin B-CDK1 complex and Aurora A, are now shown to cooperate with the small G protein RALA and its effector RALBP1 to promote DRP1 phosphorylation and mitochondrial fission.

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Figures

Figure 1
Figure 1
Mitosis-specific mitochondrial fission involves the phosphorylation of DRP1. Mitochondrial morphology is coordinated with the cell cycle. During metaphase, in which condensed chromosomes align in the middle of the cell, mitotic kinase Aurora A phosphorylates RALA, which relocalizes to mitochondria. This encourages the formation of a complex consisting of phosphorylated RALA, RALBP1and cyclin B–CDK1 on mitochondria, and mediates the phosphorylation of DRP1. Finally, oligomeric DRP1 wraps around the mitochondrial surface and mitochondrial division ensues.
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