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. 2008:2:357-62.
doi: 10.4137/cmo.s569. Epub 2008 Apr 28.

The 'Pokemon' (ZBTB7) Gene: No Evidence of Association with Sporadic Breast Cancer

Antonio Salas  1 , Ana Vega, Roger L Milne, Manuel García-Magariños, Alvaro Ruibal, Javier Benítez, Angel Carracedo
Affiliations

The 'Pokemon' (ZBTB7) Gene: No Evidence of Association with Sporadic Breast Cancer

Antonio Salas et al. Clin Med Oncol. 2008.

Abstract

It has been proposed that the excess of familiar risk associated with breast cancer could be explained by the cumulative effect of multiple weakly predisposing alleles. The transcriptional repressor FBI1, also known as Pokemon, has recently been identified as a critical factor in oncogenesis. This protein is encoded by the ZBTB7 gene. Here we aimed to determine whether polymorphisms in ZBTB7 are associated with breast cancer risk in a sample of cases and controls collected in hospitals from North and Central Spanish patients. We genotyped 15 SNPs in ZBTB7, including the flanking regions, with an average coverage of 1 SNP/2.4 Kb, in 360 sporadic breast cancer cases and 402 controls. Comparison of allele, genotype and haplotype frequencies between cases and controls did not reveal associations using Pearson's chi-square test and a permutation procedure to correct for multiple test. In this, the first study of the ZBTB7 gene in relation to, sporadic breast cancer, we found no evidence of an association.

Keywords: POKEMON; ZBTB7; association study; breast cancer; case-control.

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Figures

Figure 1
Figure 1
D′ pairwise linkage disequilibrium values of ZBTB7 markers in control individuals.
Figure 2
Figure 2
Haplotype block structure in our control individuals and HapMap information for the CEPH dataset (top).
See this image and copyright information in PMC

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