Developmentally degraded directional selectivity of the auditory cortex can be restored by auditory discrimination training in adults

Abstract

Sound localization is one of the most important tasks performed by the auditory system. Studies have shown that intensive training can remediate deteriorated frequency representations and temporal information processing in the adult primary auditory cortex (A1) induced by early post-natal pulsed noise exposure. Here we demonstrate that intensive sound location discrimination training improved the dysfunctional sound azimuth selectivity degraded by early post-natal pulsed noise exposure. Rats exposed to pulsed white noise during a post-natal critical period were successfully trained to identify a target sound stimulus with specific azimuth angle that changed daily on a random schedule. Consistent with recovery of behavioral accuracy for sound-azimuth discriminations, we found that the average angular range (AR) of A1 neuronal azimuth selective curves in trained noise-raised rats was not significantly different from that measured in control rats, while the average AR of A1 neurons in untrained noise-raised rats was significantly higher, indicating that these neurons were less direction selective. Directional selectivity of A1 neurons was normalized by training, thus demonstrating the benefits of sensory discrimination training as a strategy for restoring auditory function in adult mammals damaged by sensory disruption during critical periods of cortical development.