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. 1990:26 Suppl:S33-5.
doi: 10.1007/BF00685414.

Phase II study of carboplatin/ifosfamide in untreated advanced cervical cancer

H Kühnle  1 , H G Meerpohl, W Eiermann, S Röben, L Lenaz, W Achterrath
Affiliations

Phase II study of carboplatin/ifosfamide in untreated advanced cervical cancer

H Kühnle et al. Cancer Chemother Pharmacol. 1990.

Abstract

A total of 32 patients with advanced squamous-cell carcinoma of the cervix were treated with 300 mg/m2 i.v. carboplatin and 5 g/m2 ifosfamide as a 24-h i.v. infusion, both given on day 1 every 4 weeks. In all, 3 (9%) complete responses (CRs) and 19 (59%) objective responses (CR + PR) were achieved in 32 patients. Myelosuppression with leukopenia and/or thrombocytopenia of WHO grade 4 in 28% and 13% of patients, respectively, was the main toxicity. The results of our study suggest that carboplatin/ifosfamide is active as neoadjuvant treatment in advanced cervical cancer.

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