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. 2011 Dec;118(13):1665-8.
doi: 10.1111/j.1471-0528.2011.03133.x. Epub 2011 Sep 6.

Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study

M M Skubisz  1 , J Li, E M Wallace, S Tong
Affiliations

Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study

M M Skubisz et al. BJOG. 2011 Dec.

Erratum in

  • BJOG. 2012 Jan;119(1):123. Lee, J [corrected to Li, J]

Abstract

In current protocols for the medical management of ectopic pregnancies, the first indication of treatment response is obtained no sooner than day 7. We examined whether human chorionic gonadotrophin (βhCG) trends between days 0 and 4 after methotrexate provide an earlier indication of the likely outcome. Of 33 patients where serum βhCG dropped between days 0 and 4 after methotrexate, the ectopic pregnancy was resolved in 88% of cases without further treatment. Of 12 women where serum βhCG rose between days 0 and 4, only 42% had treatment success. A fall in βhCG between days 0 and 4 after treatment with methotrexate for ectopic pregnancy predicts a high likelihood of treatment success.

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