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. 1990 May 15;46(5):502-5.
doi: 10.1007/BF01954247.

Effects of isoxazolyl-naphthoquinoneimines on growth and oxygen radical production in Trypanosoma cruzi and Crithidia fasciculata

M N de Tarlovsky  1 , S G Goijman, M P Molina Portela, A O Stoppani
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Effects of isoxazolyl-naphthoquinoneimines on growth and oxygen radical production in Trypanosoma cruzi and Crithidia fasciculata

M N de Tarlovsky et al. Experientia. .

Abstract

Several 4-(aminomethylisoxazolyl)-1,2-naphthoquinones inhibited growth and DNA synthesis in Trypanosoma cruzi and stimulated O2 uptake and O2-. generation by the parasite epimastigotes and their mitochondrial and microsomal membranes; these results support the idea that oxygen radicals play a role in quinone toxicity. Maximal effects on respiration and O2-. generation were observed with antimycin-inhibited cells. Similar results as well as stimulation of H2O2 production were obtained with Crithidia fasciculata despite the presence of catalase in this organism.

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References

    1. Pharmacol Ther. 1987;35(1-2):57-162 - PubMed
    1. Mol Biochem Parasitol. 1987 Jan 15;22(2-3):125-33 - PubMed
    1. Biochem J. 1978 Nov 1;175(2):431-9 - PubMed
    1. Exp Parasitol. 1977 Jun;42(1):142-9 - PubMed
    1. Trans R Soc Trop Med Hyg. 1982;76(4):493-6 - PubMed

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