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Case Reports
. 2011 Jul;2(3):187-8.
doi: 10.4103/0976-500X.83285.

Cross sensitivity between ciprofloxacin and levofloxacin for an immediate hypersensitivity reaction

Ashish P Anovadiya  1 , Manish J Barvaliya, Tejas K Patel, C B Tripathi
Affiliations
Case Reports

Cross sensitivity between ciprofloxacin and levofloxacin for an immediate hypersensitivity reaction

Ashish P Anovadiya et al. J Pharmacol Pharmacother. 2011 Jul.

Abstract

Seven years old male child (24 kg weight) diagnosed as a case of sub acute appendicitis treated with ciprofloxacin, immediately developed multiple erythmatous papules. Reaction subsided after withholding ciprofloxacin and treatment with dexamethasone and chlorpheneramine maleate. It was developed again when treated with levofloxacin and subsided after withdrawal. IgE binding at 7(th) position of core structure of fluoroquinolones likely to be the mechanism. As all the fluoroquinolones have similar core structure, hypersensitivity to one may have cross sensitivity to other fluoroquinolones. It is advisable to avoid other fluoroquinolones and switch over to other group of antibiotics when hypersensitivity to one occurs.

Keywords: Cross sensitivity; ciprofloxacin; fluoroquinolones; levofloxacin.

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Conflict of interest statement

Conflict of Interest: None declared.

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