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Case Reports
. 2011 Jul;15(3):217-9.
doi: 10.4103/2230-8210.83412.

Adrenocortical carcinoma: Report of two cases

C Aparna  1 , I V Renuka, G Saila Bala, P Annapurna
Affiliations
Case Reports

Adrenocortical carcinoma: Report of two cases

C Aparna et al. Indian J Endocrinol Metab. 2011 Jul.

Abstract

Adrenocortical carcinoma (ACC) is a rare neoplasm with a slight predilection for female patients. We report two cases of ACC. The first case was of a 7-year-old girl who presented with clitoromegaly. The second case was of a 22-Year-old female who presented with a lump in the abdomen and features of Cushing's syndrome with virilization.The clinical, biochemical, histological features along with differential diagnosis are discussed. These cases are presented because of their rarity, and also to highlight the importance of differentiating ACC from an adenoma particularly in pediatric patients.

Keywords: Adrenocortical carcinoma; Cushing's syndrome; clitoromegaly.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Tumor cells arranged in thick trabecular patterns (H and E, ×400)
Figure 2
Figure 2
Case 2 patient showing cushingoid features and hirsutism
Figure 3
Figure 3
Tumor showing vascular invasion (H and E, ×400)
Figure 4
Figure 4
Tumor cells showing bizarre nuclei (H and E, ×400)
Figure 5
Figure 5
Tumor cells showing inhibin positivity and inset shows chromogranin negativity (×400)
See this image and copyright information in PMC

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