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. 2011 Nov;49(11):3986-9.
doi: 10.1128/JCM.01242-11. Epub 2011 Sep 7.

Containment of an outbreak of KPC-3-producing Klebsiella pneumoniae in Italy

Antonella Agodi  1 , Evangelia Voulgari, Martina Barchitta, Leda Politi, Vasiliki Koumaki, Nicholas Spanakis, Loredana Giaquinta, Giovanna Valenti, Maria Antonietta Romeo, Athanassios Tsakris
Affiliations

Containment of an outbreak of KPC-3-producing Klebsiella pneumoniae in Italy

Antonella Agodi et al. J Clin Microbiol. 2011 Nov.

Abstract

From March 2009 to May 2009, 24 carbapenem-resistant Klebsiella pneumoniae isolates were recovered from 16 patients hospitalized in an Italian intensive care unit (ICU). All isolates contained KPC-3 carbapenemase and belonged to a single pulsed-field gel electrophoresis (PFGE) clone of multilocus sequence type 258 (designated as ST258). A multimodal infection control program was put into effect, and the spread of the KPC-3-producing K. pneumoniae clone was ultimately controlled without closing the ICU to new admissions. Reinforced infection control measures and strict monitoring of the staff adherence were necessary for the control of the outbreak.

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Figures

Fig. 1.
Fig. 1.
Epidemic curves of the carbapenem-resistant clone (PFGE type E) and of the carbapenem-susceptible clone (PFGE type A) in the ICU of the Cannizzaro hospital. Isolates of both clonal types are represented according to their weekly distribution over a 9-month period of time. Arrows designate when the first and second rounds of infection control interventions were begun.
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