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Comparative Study
. 1990 Jun 14;345(6276):593-8.
doi: 10.1038/345593a0.

Three-dimensional structure of the free radical protein of ribonucleotide reductase

P Nordlund  1 , B M Sjöberg, H Eklund
Affiliations
Comparative Study

Three-dimensional structure of the free radical protein of ribonucleotide reductase

P Nordlund et al. Nature. .

Abstract

The enzyme ribonucleotide reductase furnishes precursors for the DNA synthesis of all living cells. One of its constituents, the free radical protein, has an unusual alpha-helical structure. There are two iron centres that are about 25 A apart in the dimeric molecule. Tyrosine 122, which harbours the stable free radical necessary for the activity of ribonucleotide reductase, is buried inside the protein and is located 5 A from the closest iron atom.

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