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Meta-Analysis
. 2011 Sep 7;2011(9):CD001544.
doi: 10.1002/14651858.CD001544.pub4.

Mechanical bowel preparation for elective colorectal surgery

Katia F Güenaga  1 , Delcio Matos, Peer Wille-Jørgensen
Affiliations
Meta-Analysis

Mechanical bowel preparation for elective colorectal surgery

Katia F Güenaga et al. Cochrane Database Syst Rev. .

Abstract

Background: The presence of bowel contents during colorectal surgery has been related to anastomotic leakage, but the belief that mechanical bowel preparation (MBP) is an efficient agent against leakage and infectious complications is based on observational data and expert opinions only.An enema before the rectal surgery to clean the rectum and facilitate the manipulation for the mechanical anastomosis is used for many surgeons. This is analysed separately

Objectives: To determine the security and effectiveness of MBP on morbidity and mortality in colorectal surgery.

Search strategy: Publications describing trials of MBP before elective colorectal surgery were sought through searches of MEDLINE, EMBASE, LILACS, IBECS and The Cochrane Library; by handsearching relevant medical journals and conference proceedings, and through personal communication with colleagues.Searches were performed December 1, 2010.

Selection criteria: Randomised controlled trials (RCTs) including participants submitted for elective colorectal surgery. Eligible interventions included any type of MBP compared with no MBP. Primary outcomes included anastomosis leakage - both rectal and colonic - and combined figures. Secondary outcomes included mortality, peritonitis, reoperation, wound infection, extra-abdominal complications, and overall surgical site infections.

Data collection and analysis: Data were independently extracted and checked. The methodological quality of each trial was assessed. Details of randomisation, blinding, type of analysis, and number lost to follow up were recorded. For analysis, the Peto-Odds Ratio (OR) was used as the default (no statistical heterogeneity was observed).

Main results: At this update six trials and a new comparison (Mechanical bowel preparation versus enema) were added. Altogether eighteen trials were analysed, with 5805 participants; 2906 allocated to MBP (Group A), and 2899 to no preparation (Group B), before elective colorectal surgery.For the comparison Mechanical Bowel Preparation Versus No Mechanical Bowel Preparation results were:1. Anastomotic leakage for low anterior resection: 8.8% (38/431) of Group A, compared with 10.3% (43/415) of Group B; Peto OR 0.88 [0.55, 1.40].2. Anastomotic leakage for colonic surgery: 3.0% (47/1559) of Group A, compared with 3.5% (56/1588) of Group B; Peto OR 0.85 [0.58, 1.26].3. Overall anastomotic leakage: 4.4% (101/2275) of Group A, compared with 4.5% (103/2258) of Group B; Peto OR 0.99 [0.74, 1.31].4. Wound infection: 9.6% (223/2305) of Group A, compared with 8.5% (196/2290) of Group B; Peto OR 1.16 [0.95, 1.42].Sensitivity analyses did not produce any differences in overall results.For the comparison Mechanical Bowel Preparation (A) Versus Rectal Enema (B) results were:1. Anastomotic leakage after rectal surgery: 7.4% (8/107) of Group A, compared with 7.9% (7/88) of Group B; Peto OR 0.93 [0.34, 2.52].2. Anastomotic leakage after colonic surgery: 4.0% (11/269) of Group A, compared with 2.0% (6/299) of Group B; Peto OR 2.15 [0.79, 5.84].3. Overall anastomotic leakage: 4.4% (27/601) of Group A, compared with 3.4% (21/609) of Group B; Peto OR 1.32 [0.74, 2.36].4. Wound infection: 9.9% (60/601) of Group A, compared with 8.0% (49/609) of Group B; Peto OR 1.26 [0.85, 1.88].

Authors' conclusions: Despite the inclusion of more studies with a total of 5805 participants, there is no statistically significant evidence that patients benefit from mechanical bowel preparation, nor the use of rectal enemas. In colonic surgery the bowel cleansing can be safely omitted and induces no lower complication rate. The few studies focused in rectal surgery suggested that mechanical bowel preparation could be used selectively, even though no significant effect was found. Further research on patients submitted for elective rectal surgery, below the peritoneal verge, in whom bowel continuity is restored, and studies with patients submitted to laparoscopic surgeries are still warranted.

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Conflict of interest statement

There are no conflicts of interest relating to this review.

Figures

1.1
1.1. Analysis
Comparison 1 Mechanical bowel preparation versus no preparation, Outcome 1 Anastomosis leakage stratified for colonic or rectal surgery.
1.2
1.2. Analysis
Comparison 1 Mechanical bowel preparation versus no preparation, Outcome 2 Overall anastomotic leakage for colorectal surgery.
1.3
1.3. Analysis
Comparison 1 Mechanical bowel preparation versus no preparation, Outcome 3 Mortality.
1.4
1.4. Analysis
Comparison 1 Mechanical bowel preparation versus no preparation, Outcome 4 Peritonitis.
1.5
1.5. Analysis
Comparison 1 Mechanical bowel preparation versus no preparation, Outcome 5 Reoperation.
1.6
1.6. Analysis
Comparison 1 Mechanical bowel preparation versus no preparation, Outcome 6 Wound infection.
1.7
1.7. Analysis
Comparison 1 Mechanical bowel preparation versus no preparation, Outcome 7 Infectious extra‐abdominal complications.
1.8
1.8. Analysis
Comparison 1 Mechanical bowel preparation versus no preparation, Outcome 8 Non‐infectious extra‐abdominal complications.
1.9
1.9. Analysis
Comparison 1 Mechanical bowel preparation versus no preparation, Outcome 9 Sensitivity analysis 1 ‐ Including only studies with adequate randomisation.
1.10
1.10. Analysis
Comparison 1 Mechanical bowel preparation versus no preparation, Outcome 10 Sensitivity analysis 2 ‐ Studies including only patients with anastomosis.
2.1
2.1. Analysis
Comparison 2 Mechanical bowel preparation versus rectal enema, Outcome 1 Anastomotic leakage for colorectal surgery.
2.2
2.2. Analysis
Comparison 2 Mechanical bowel preparation versus rectal enema, Outcome 2 Overall anastomotic leakage.
2.3
2.3. Analysis
Comparison 2 Mechanical bowel preparation versus rectal enema, Outcome 3 Mortality.
2.4
2.4. Analysis
Comparison 2 Mechanical bowel preparation versus rectal enema, Outcome 4 Peritonitis / Abscess.
2.5
2.5. Analysis
Comparison 2 Mechanical bowel preparation versus rectal enema, Outcome 5 Reoperation.
2.6
2.6. Analysis
Comparison 2 Mechanical bowel preparation versus rectal enema, Outcome 6 Wound infection.
See this image and copyright information in PMC

Update of

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References to studies included in this review

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MeSH terms