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. 2011 Oct 18;23(39):4509-15.
doi: 10.1002/adma.201102371. Epub 2011 Sep 8.

Nanogel star polymer architectures: a nanoparticle platform for modular programmable macromolecular self-assembly, intercellular transport, and dual-mode cargo delivery

Victor Y Lee  1 , Karen Havenstrite, Melia Tjio, Melanie McNeil, Helen M Blau, Robert D Miller, Joseph Sly
Affiliations

Nanogel star polymer architectures: a nanoparticle platform for modular programmable macromolecular self-assembly, intercellular transport, and dual-mode cargo delivery

Victor Y Lee et al. Adv Mater. .
No abstract available

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Figures

Figure 1
Figure 1
Top: GPC traces of the linear arm 1, the hydrophobic core nanogel star polymer 3, and the core/shell nanogel star polymer 5 showing their high structural uniformity and (inset) photo graph of the result from a single large-scale synthesis of 3. Bottom: AFM image of 5 deposited from aqueous solution that shows 5 to be discrete uniform globular nanoparticles.
Figure 2
Figure 2
Cartoon representation of the structural versatility, in terms of controlled nanoparticle size and polyvalency, demonstrated by the formation of 2d–f.
Figure 3
Figure 3
Spectroscopic analyses of the modular, tandem self-assembly processes used to install dual functionally into the nanogel star polymer delivery platform. Top: Absorption spectra of the occlusion complex 7a formed from 5 and porphyrin 6a and a photograph (inset) of the aqueous formulations of 5, 6a (suspension), and 7a,b. Bottom: Electrophoretic analysis of the siRNA complexes with 7a showing the binding of between 5–10 strands of siRNA per dual-functionalized nanoparticle 9.
Figure 4
Figure 4
Top: High-resolution confocal fluorescence microscopy image of a murine muscle myoblast cell after incubation with 7a showing that the internalized fluorescent nanoparticles have crossed the cellular membrane and are located throughout the cytoplasm of the cell. Bottom: Transmission light microscopy image (right) and confocal fluorescence microscopy image (left) of murine muscle myoblast cells differentiating into myotubes (highlighted by arrows), indicating functional viability of the cells post internalization of 7a.
Scheme 1
Scheme 1
Conditions used in the rapid, room-temperature, arm first synthesis of nanogel star polymer 3, its core first use to create water-soluble core/shell (hydrophobic-hydrophillic) nanogel star polymer 5, and its subsequent use as a modular preprogrammed tandem-mode macromolecular self-assembly platform 7 and 9 to provide simultaneous expression of functionality (e.g., vehicle for fluorescent delivery of genetic materials shown).
See this image and copyright information in PMC

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