Lipoproteins of Enterococcus faecalis: bioinformatic identification, expression analysis and relation to virulence
- PMID: 21903750
- DOI: 10.1099/mic.0.053314-0
Lipoproteins of Enterococcus faecalis: bioinformatic identification, expression analysis and relation to virulence
Abstract
Enterococcus faecalis is a ubiquitous bacterium that is capable of surviving in a broad range of natural environments, including the human host, as either a natural commensal or an opportunistic pathogen involved in severe hospital-acquired infections. How such opportunistic pathogens cause fatal infections is largely unknown but it is likely that they are equipped with sophisticated systems to perceive external signals and interact with eukaryotic cells. Accordingly, being partially exposed at the cell exterior, some surface-associated proteins are involved in several steps of the infection process. Among them are lipoproteins, representing about 25 % of the surface-associated proteins, which could play a major role in bacterial virulence processes. This review focuses on the identification of 90 lipoprotein-encoding genes in the genome of the E. faecalis V583 clinical strain and their putative roles, and provides a transcriptional comparison of microarray data performed in environmental conditions including blood and urine. Taken together, these data suggest a potential involvement of lipoproteins in E. faecalis virulence, making them serious candidates for vaccine production.
Similar articles
-
Transcriptional response of Enterococcus faecalis V583 to erythromycin.Antimicrob Agents Chemother. 2005 Jun;49(6):2246-59. doi: 10.1128/AAC.49.6.2246-2259.2005. Antimicrob Agents Chemother. 2005. PMID: 15917518 Free PMC article.
-
The transcriptome of the nosocomial pathogen Enterococcus faecalis V583 reveals adaptive responses to growth in blood.PLoS One. 2009 Nov 4;4(11):e7660. doi: 10.1371/journal.pone.0007660. PLoS One. 2009. PMID: 19888459 Free PMC article.
-
Surface protein EF3314 contributes to virulence properties of Enterococcus faecalis.Int J Artif Organs. 2009 Sep;32(9):611-20. doi: 10.1177/039139880903200910. Int J Artif Organs. 2009. PMID: 19856273 Free PMC article.
-
Relationships between oxidative stress response and virulence in Enterococcus faecalis.J Mol Microbiol Biotechnol. 2007;13(1-3):140-6. doi: 10.1159/000103605. J Mol Microbiol Biotechnol. 2007. PMID: 17693721 Review.
-
Review of virulence factors of enterococcus: an emerging nosocomial pathogen.Indian J Med Microbiol. 2009 Oct-Dec;27(4):301-5. doi: 10.4103/0255-0857.55437. Indian J Med Microbiol. 2009. PMID: 19736397 Review.
Cited by
-
Conserved surface accessible nucleoside ABC transporter component SP0845 is essential for pneumococcal virulence and confers protection in vivo.PLoS One. 2015 Feb 17;10(2):e0118154. doi: 10.1371/journal.pone.0118154. eCollection 2015. PLoS One. 2015. PMID: 25689507 Free PMC article.
-
Surface-Associated Lipoproteins Link Enterococcus faecalis Virulence to Colitogenic Activity in IL-10-Deficient Mice Independent of Their Expression Levels.PLoS Pathog. 2015 Jun 12;11(6):e1004911. doi: 10.1371/journal.ppat.1004911. eCollection 2015 Jun. PLoS Pathog. 2015. PMID: 26067254 Free PMC article.
-
Coordinate regulation of Gram-positive cell surface components.Curr Opin Microbiol. 2012 Apr;15(2):204-10. doi: 10.1016/j.mib.2011.12.011. Epub 2012 Jan 10. Curr Opin Microbiol. 2012. PMID: 22236805 Free PMC article.
-
Competent but complex communication: The phenomena of pheromone-responsive plasmids.PLoS Pathog. 2020 Apr 2;16(4):e1008310. doi: 10.1371/journal.ppat.1008310. eCollection 2020 Apr. PLoS Pathog. 2020. PMID: 32240270 Free PMC article. Review.
-
The zoonotic potential of daptomycin non-susceptible enterococci.Zoonoses Public Health. 2015 Feb;62(1):1-6. doi: 10.1111/zph.12091. Epub 2013 Nov 26. Zoonoses Public Health. 2015. PMID: 24274811 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases