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. 2011 Sep 1;67(Pt 9):979-84.
doi: 10.1107/S1744309111029204. Epub 2011 Aug 13.

Structural genomics of infectious disease drug targets: the SSGCID

Robin Stacy  1 , Darren W Begley, Isabelle Phan, Bart L Staker, Wesley C Van Voorhis, Gabriele Varani, Garry W Buchko, Lance J Stewart, Peter J Myler
Affiliations

Structural genomics of infectious disease drug targets: the SSGCID

Robin Stacy et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. .

Abstract

The Seattle Structural Genomics Center for Infectious Disease (SSGCID) is a consortium of researchers at Seattle BioMed, Emerald BioStructures, the University of Washington and Pacific Northwest National Laboratory that was established to apply structural genomics approaches to drug targets from infectious disease organisms. The SSGCID is currently funded over a five-year period by the National Institute of Allergy and Infectious Diseases (NIAID) to determine the three-dimensional structures of 400 proteins from a variety of Category A, B and C pathogens. Target selection engages the infectious disease research and drug-therapy communities to identify drug targets, essential enzymes, virulence factors and vaccine candidates of biomedical relevance to combat infectious diseases. The protein-expression systems, purified proteins, ligand screens and three-dimensional structures produced by SSGCID constitute a valuable resource for drug-discovery research, all of which is made freely available to the greater scientific community. This issue of Acta Crystallographica Section F, entirely devoted to the work of the SSGCID, covers the details of the high-throughput pipeline and presents a series of structures from a broad array of pathogenic organisms. Here, a background is provided on the structural genomics of infectious disease, the essential components of the SSGCID pipeline are discussed and a survey of progress to date is presented.

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Figures

Figure 1
Figure 1
The SSGCID pipeline. A 17-tiered serial escalation approach is utilized by the SSGCID, with activities performed at Seattle BioMed (pink), UW-PPG (blue), Emerald BioStructures (green) and UW-NMR or PNNL (orange). Each Tier utilizes the approach described at the bottom of the figure. The numbers in the hexagons indicate the numbers of targets which have successfully passed through each step of the pipeline.
Figure 2
Figure 2
Cumulative status at key steps of targets in the SSGCID pipeline.
Figure 3
Figure 3
Summary of community-request targets by kingdom (pie chart) and genus (tables).
See this image and copyright information in PMC

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