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Review
. 2011 Sep 9;11(10):685-92.
doi: 10.1038/nri3062.

Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response

Katherine Y King  1 , Margaret A Goodell
Affiliations
Review

Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response

Katherine Y King et al. Nat Rev Immunol. .

Abstract

Cells of the innate and adaptive immune systems are the progeny of a variety of haematopoietic precursors, the most primitive of which is the haematopoietic stem cell. Haematopoietic stem cells have been thought of generally as dormant cells that are only called upon to divide under extreme conditions, such as bone marrow ablation through radiation or chemotherapy. However, recent studies suggest that haematopoietic stem cells respond directly and immediately to infections and inflammatory signals. In this Review, we summarize the current literature regarding the effects of infection on haematopoietic stem cell function and how these effects may have a pivotal role in directing the immune response from the bone marrow.

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References

    1. Hotchkiss RS, et al. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol. 2001;166 (11):6952–6963. - PubMed
    1. Ueda Y, Cain DW, Kuraoka M, Kondo M, Kelsoe G. IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia. The Journal of Immunology. 2009;182 (10):6477–6484. - PMC - PubMed
    1. Wilson A, et al. Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair. Cell. 2008;135 (6):1118–1129. - PubMed
    1. Shahbazian L, et al. Escherichia coli pneumonia enhances granulopoiesis and the mobilization of myeloid progenitor cells into the systemic circulation. Critical Care Medicine. 2004;32 (8):1740–1746. - PubMed
    1. Quinton LJ, et al. The granulocyte colony-stimulating factor response after intrapulmonary and systemic bacterial challenges. J Infect Dis. 2002;185 (10):1476–1482. - PubMed

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