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. 2011 Jun;3(3):107-17.
doi: 10.1177/1756287211407543.

Management of invasive bladder cancer in patients who are not candidates for or decline cystectomy

Arjun Balar  1 , Dean F Bajorin, Matthew I Milowsky
Affiliations

Management of invasive bladder cancer in patients who are not candidates for or decline cystectomy

Arjun Balar et al. Ther Adv Urol. 2011 Jun.

Abstract

Bladder cancer is a common malignancy seen in older adults with coexisting medical illnesses. The management of patients with muscle invasive disease includes perioperative chemotherapy and radical cystectomy; however, patients may decline surgery and older patients with comorbid conditions may not be candidates for surgery and thus alternative treatment strategies are needed. Trimodality bladder preservation protocols for muscle invasive bladder cancer have generally included only those patients who are candidates for a salvage cystectomy. In this review, we discuss the current status of bladder preservation treatment options for patients with muscle-invasive disease who are not candidates for cystectomy or who decline surgery and highlight the need for clinical trials investigating novel treatment approaches in this older patient population.

Keywords: TURBT; bladder cancer; bladder preservation; cystectomy; octogenarians; radiation therapy; transitional cell carcinoma; transurethral resection of bladder tumor; urothelial carcinoma.

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Figures

Figure 1.
Figure 1.
Options for the management of invasive bladder cancer in patients who are not candidates for cystectomy.
See this image and copyright information in PMC

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