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Review
. 2011;21(5):333-47; quiz follow 347.

Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part I. Classification, epidemiology, pathophysiology, genetics, clinical symptoms, and diagnosis

T Caballero  1 , M L Baeza, R Cabañas, A Campos, S Cimbollek, C Gómez-Traseira, T González-Quevedo, M Guilarte, G J Jurado-Palomo, J I Larco, M C López-Serrano, M López-Trascasa, C Marcos, J M Muñoz-Caro, M Pedrosa, N Prior, M Rubio, A Sala-Cunill; Spanish Study Group on Bradykinin-Induced Angioedema; Grupo Español de Estudio del Angioedema mediado por Bradicinina
Affiliations
  • PMID: 21905496
Free article
Review

Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part I. Classification, epidemiology, pathophysiology, genetics, clinical symptoms, and diagnosis

T Caballero et al. J Investig Allergol Clin Immunol. 2011.
Free article

Erratum in

  • J Investig Allergol Clin Immunol. 2012;22(2):3 p following 153

Abstract

Background: There are no Spanish guidelines or consensus statement on bradykinin-induced angioedema.

Aim: To review the pathophysiology, genetics, and clinical symptoms of the different types of bradykinin-induced angioedema and to draft a consensus statement in light of currently available scientific evidence and the experience of experts. This statement will serve as a guideline to health professionals.

Methods: The consensus was led by the Spanish Study Group on Bradykinin-Induced Angioedema (SGBA), a working group of the Spanish Society of Allergology and Clinical Immunology. A review was conducted of scientific papers on different types of bradykinin-induced angioedema (hereditary and acquired angioedema due to C1 inhibitor deficiency, hereditary angioedema related to estrogens, angioedema induced by angiotensin-converting enzyme inhibitors). Several discussion meetings of the SGBA were held in Madrid to reach the consensus.

Results: The pathophysiology, genetics, and clinical symptoms of the different types of angioedema are reviewed. Diagnostic approaches are discussed and the consensus reached is described.

Conclusions: A review of bradykinin-induced angioedema and a consensus on diagnosis are presented.

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