Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Sep 11;17(10):1231-4.
doi: 10.1038/nm.2452.

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

Tomoki Nakashima  1 , Mikihito Hayashi, Takanobu Fukunaga, Kosaku Kurata, Masatsugu Oh-Hora, Jian Q Feng, Lynda F Bonewald, Tatsuhiko Kodama, Anton Wutz, Erwin F Wagner, Josef M Penninger, Hiroshi Takayanagi
Affiliations

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

Tomoki Nakashima et al. Nat Med. .

Abstract

Osteocytes embedded in bone have been postulated to orchestrate bone homeostasis by regulating both bone-forming osteoblasts and bone-resorbing osteoclasts. We find here that purified osteocytes express a much higher amount of receptor activator of nuclear factor-κB ligand (RANKL) and have a greater capacity to support osteoclastogenesis in vitro than osteoblasts and bone marrow stromal cells. Furthermore, the severe osteopetrotic phenotype that we observe in mice lacking RANKL specifically in osteocytes indicates that osteocytes are the major source of RANKL in bone remodeling in vivo.

PubMed Disclaimer

Comment in

References

    1. Nature. 1999 Jan 28;397(6717):315-23 - PubMed
    1. Nat Rev Immunol. 2007 Apr;7(4):292-304 - PubMed
    1. J Mol Med (Berl). 2011 Jul;89(7):647-56 - PubMed
    1. Cell Tissue Res. 2006 Feb;323(2):263-71 - PubMed
    1. Bone. 2009 Oct;45(4):682-92 - PubMed

Publication types

MeSH terms