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Review
. 2011 Nov;32(11):1311-20.
doi: 10.1038/aps.2011.103. Epub 2011 Sep 12.

Macro-management of microRNAs in cell cycle progression of tumor cells and its implications in anti-cancer therapy

Lin-hui Liang  1 , Xiang-huo He
Affiliations
Review

Macro-management of microRNAs in cell cycle progression of tumor cells and its implications in anti-cancer therapy

Lin-hui Liang et al. Acta Pharmacol Sin. 2011 Nov.

Abstract

The cell cycle, which is precisely controlled by a number of regulators, including cyclins and cyclin-dependent kinases (CDKs), is crucial for the life cycle of mammals. Cell cycle dysregulation is implicated in many diseases, including cancer. Recently, compelling evidence has been found that microRNAs play important roles in the regulation of cell cycle progression by modulating the expression of cyclins, CDKs and other cell cycle regulators. Herein, the recent findings on the regulation of the cell cycle by microRNAs are summarized, and the potential implications of miRNAs in anti-cancer therapies are discussed.

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Figures

Figure 1
Figure 1
MicroRNAs in the control of cell cycle progression.
See this image and copyright information in PMC

References

    1. Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999;13:1501–12. - PubMed
    1. Yang J, Xu ZP, Huang Y, Hamrick HE, Duerksen-Hughes PJ, Yu YN. ATM and ATR: sensing DNA damage. World J Gastroenterol. 2004;10:155–60. - PMC - PubMed
    1. Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer. 2009;9:153–66. - PubMed
    1. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004;5:522, 31. - PubMed
    1. Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19:92–105. - PMC - PubMed

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