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Clinical Trial
. 1990 Apr;25(4):673-8.
doi: 10.1093/jac/25.4.673.

A comparison of aztreonam/metronidazole and cefotaxime/metronidazole in elective colorectal surgery: antimicrobial prophylaxis must include gram-positive cover

D L Morris  1 , S R Wilson, J Pain, K F Edwardson, J Jones, C Strachan, R Slack
Affiliations
Clinical Trial

A comparison of aztreonam/metronidazole and cefotaxime/metronidazole in elective colorectal surgery: antimicrobial prophylaxis must include gram-positive cover

D L Morris et al. J Antimicrob Chemother. 1990 Apr.

Abstract

Aztreonam/metronidazole and cefotaxime/metronidazole were compared in a prospective trial in 154 patients undergoing elective colorectal surgery. Three antibiotic doses were given over 16 hours. A significant excess of wound sepsis in the aztreonam group was seen (23/71 vs 9/70 chi 2 6.60; P less than 0.01). Sepsis was almost invariably due to Gram-positive organisms and, in particular, Staphylococcus aureus.

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