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. 2011 Oct 28;74(10):2261-4.
doi: 10.1021/np100872k. Epub 2011 Sep 12.

Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity

Yee Meng Chong  1 , Wai Fong Yin, Chia Yong Ho, Mohamad Rais Mustafa, A Hamid A Hadi, Khalijah Awang, Putri Narrima, Chong-Lek Koh, David R Appleton, Kok-Gan Chan
Affiliations

Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity

Yee Meng Chong et al. J Nat Prod. .

Abstract

A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further.

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