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. 2011 Sep 12:8:436.
doi: 10.1186/1743-422X-8-436.

Novel snake papillomavirus does not cluster with other non-mammalian papillomaviruses

Christian E Lange  1 , Claude Favrot, Mathias Ackermann, Jessica Gull, Elisabeth Vetsch, Kurt Tobler
Affiliations

Novel snake papillomavirus does not cluster with other non-mammalian papillomaviruses

Christian E Lange et al. Virol J. .

Abstract

Papillomaviruses (PVs) are associated with the development of neoplasias and have been found in several different species, most of them in humans and other mammals. We identified, cloned and sequenced PV DNA from pigmented papilloma-like lesions of a diamond python (Morelia spilota spilota). This represents the first complete PV genome discovered in a Squamata host (MsPV1). It consists of 7048 nt and contains the characteristic open reading (ORF) frames E6, E7, E1, E2, L1 and L2. The L1 ORF sequence showed the highest percentage of sequence identities to human PV5 (57.9%) and Caribbean manatee (Trichechus manatus) PV1 (55.4%), thus, establishing a new clade. According to phylogenetic analysis, the MsPV1 genome clusters with PVs of mammalian rather than sauropsid hosts.

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Figures

Figure 1
Figure 1
Schematic presentation of the Morelia spilota spilota papillomavirus genome and open reading frames (ORFs). Genomes are divided into sections: early genes (Early), late genes (Late) and non-coding regions (NCRs). Numbers indicate nucleotide positions. Nucleotide position number one is defined here as the first following the stop codon of the L1 ORFs.
Figure 2
Figure 2
Midpoint rooted Bayesian phylogenetic tree of 50 papillomaviruses (PVs). Numbers at internal nodes represent the posterior probability support values; values below 0.9 are not shown. Unclassified PVs are marked with asterisks. Arrows indicate sauropsid PVs.
See this image and copyright information in PMC

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