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Review
. 2011 Jul 21;17(27):3178-83.
doi: 10.3748/wjg.v17.i27.3178.

Innate and adaptive immunity in inflammatory bowel disease

Britta Siegmund  1 , Martin Zeitz
Affiliations
Review

Innate and adaptive immunity in inflammatory bowel disease

Britta Siegmund et al. World J Gastroenterol. .

Abstract

Inflammatory bowel diseases are the consequence of a dysregulated mucosal immune system. The mucosal immune system consists of two arms, innate and adaptive immunity, that have been studied separately for a long time. Functional studies from in vivo models of intestinal inflammation as well as results from genome-wide association studies strongly suggest a cross-regulation of both arms. The present review will illustrate this interaction by selecting examples from innate immunity and adaptive immunity, and their direct impact on each other. Broadening our view by focusing on the cross-regulated areas of the mucosal immune system will not only facilitate our understanding of disease, but furthermore will allow identification of future therapeutic targets.

Keywords: Immune system; Inflammatory bowel diseases.

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Figures

Figure 1
Figure 1
Cell populations primarily belonging to the innate immune system are marked blue, and cells primarily categorized as cells of the adaptive immune system are marked red. Purple marked cells identify the cross-link between both systems. IL: Interleukin.
See this image and copyright information in PMC

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