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. 2011 Jul 21;17(27):3229-34.
doi: 10.3748/wjg.v17.i27.3229.

Oncologic outcomes of primary and post-irradiated early stage rectal cancer: a retrospective cohort study

Chang-Zheng Du  1 , Yong-Chun Chen, Yong Cai, Wei-Cheng Xue, Jin Gu
Affiliations

Oncologic outcomes of primary and post-irradiated early stage rectal cancer: a retrospective cohort study

Chang-Zheng Du et al. World J Gastroenterol. .

Abstract

Aim: To evaluate the oncologic outcomes of primary and post-irradiated early stage rectal cancer and the effectiveness of adjuvant chemotherapy for rectal cancer patients.

Methods: Eighty-four patients with stage I rectal cancer after radical surgery were studied retrospectively and divided into ypstage I group (n = 45) and pstage I group (n = 39), according to their preoperative radiation, and compared by univariate and multivariate analysis.

Results: The median follow-up time of patients was 70 mo. No significant difference was observed in disease progression between the two groups. The 5-year disease-free survival rate was 84.4% and 92.3%, respectively (P = 0.327) and the 5-year overall survival rate was 88.9% and 92.3%, respectively, for the two groups (P = 0.692). The disease progression was not significantly associated with the pretreatment clinical stage in ypstage I group. The 5-year disease progression rate was 10.5% and 19.2%, respectively, for the patients who received adjuvant chemotherapy and for those who rejected chemotherapy in the ypstage I group (P = 0.681).

Conclusion: The oncologic outcomes of primary and post-irradiated early stage rectal cancer are similar. Patients with ypstage I rectal cancer may slightly benefit from adjuvant chemotherapy.

Keywords: Neoadjuvant radiotherapy; Rectal cancer; Total mesorectal excision.

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Figures

Figure 1
Figure 1
Five-year disease-free survival rate for patients in two groups.
Figure 2
Figure 2
Five-year overall survival rate for patients in two groups.
See this image and copyright information in PMC

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