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. 2011 Oct 21;76(20):8530-6.
doi: 10.1021/jo201530r. Epub 2011 Sep 26.

Rhodium(III)-catalyzed oxidative coupling of 5-aryl-1H-pyrazoles with alkynes and acrylates

Xingwei Li  1 , Miao Zhao
Affiliations

Rhodium(III)-catalyzed oxidative coupling of 5-aryl-1H-pyrazoles with alkynes and acrylates

Xingwei Li et al. J Org Chem. .

Abstract

[RhCp*Cl(2)](2)-catalyzed oxidative coupling of 5-aryl-1H-pyrazoles with alkynes and acrylates has been achieved using Cu(OAc)(2) as an oxidant. Coupling with alkynes afforded six-membered azacycles as a result of C-C and C-N coupling. Coupling with acrylates followed a process of diolefination and a subsequent aza-Michael cyclization.

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