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. 2011 Sep 13;9(1):27.
doi: 10.1186/1546-0096-9-27.

Rituximab resistant evans syndrome and autoimmunity in Schimke immuno-osseous dysplasia

Jakub Zieg  1 , Anna Krepelova, Alireza Baradaran-Heravi, Elena Levtchenko, Encarna Guillén-Navarro, Miroslava Balascakova, Martina Sukova, Tomas Seeman, Jiri Dusek, Nadezda Simankova, Tomas Rosik, Sylva Skalova, Jan Lebl, Cornelius F Boerkoel
Affiliations

Rituximab resistant evans syndrome and autoimmunity in Schimke immuno-osseous dysplasia

Jakub Zieg et al. Pediatr Rheumatol Online J. .

Abstract

Autoimmunity is often observed among individuals with primary immune deficiencies; however, the frequency and role of autoimmunity in Schimke immuno-osseous dysplasia (SIOD) has not been fully assessed. SIOD, which is caused by mutations of SMARCAL1, is a rare autosomal recessive disease with its prominent features being skeletal dysplasia, T cell deficiency, and renal failure. We present a child with severe SIOD who developed rituximab resistant Evans syndrome (ES). Consistent with observations in several other immunodeficiency disorders, a review of SIOD patients showed that approximately a fifth of SIOD patients have some features of autoimmune disease. To our best knowledge this case represents the first patient with SIOD and rituximab resistant ES and the first study of autoimmune disease in SIOD.

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