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Case Reports
. 2011 Nov;113(5):1188-91.
doi: 10.1213/ANE.0b013e31822b8a7d. Epub 2011 Sep 14.

Case report: Anti-N-methyl-D-aspartate receptor encephalitis and its anesthetic implications

Peter Gabriel Pryzbylkowski  1 , William Jonathan Dunkman, Renyu Liu, Linda Chen
Affiliations
Case Reports

Case report: Anti-N-methyl-D-aspartate receptor encephalitis and its anesthetic implications

Peter Gabriel Pryzbylkowski et al. Anesth Analg. 2011 Nov.

Abstract

We describe the anesthetic management and implications of 2 patients with anti-N-methyl-D-aspartate (NMDA) receptor encephalitis. Anti-NMDA receptor encephalitis is a neurological disorder caused by production of antibodies to the NMDA receptor. The NMDA receptor is the target of many drugs used in anesthesia. It is important to understand the pharmacologic interactions these anesthetics have with a disabled NMDA receptor while preparing an anesthetic plan for patients with anti-NMDA receptor encephalitis. Symptoms of the disease such as psychosis, paroxysmal sympathetic hyperactivity, and central hypoventilation pose risks to the induction and maintenance of anesthesia in these patients.

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References

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