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Comment
. 2011 Oct;80(7):692-3.
doi: 10.1038/ki.2011.175.

The next level of complexity: post-transcriptional regulation by microRNAs

Rafael Kramann  1 , Marcus J Moeller
Affiliations
Free article
Comment

The next level of complexity: post-transcriptional regulation by microRNAs

Rafael Kramann et al. Kidney Int. 2011 Oct.
Free article

Abstract

MicroRNAs (miRNAs) are endogenous, small, noncoding RNAs that regulate expression of about half of human genes. Canonical miRNA biosynthesis involves two RNase III-type proteins, Drosha and Dicer. A podocyte-specific knockout of Dicer resulted in foot process effacement. In this issue, Zhdanova et al. report on targeting Drosha in a podocyte-specific fashion. Their study demonstrates an essential role of canonical miRNAs in maintaining the fully differentiated podocyte phenotype.

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