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Review
. 2011 Sep 15;50(1):23-30.
doi: 10.1515/CCLM.2011.707.

The human epidermal growth factor receptor 2 (HER2)

Laura J Tafe  1 , Gregory J Tsongalis
Affiliations
Review

The human epidermal growth factor receptor 2 (HER2)

Laura J Tafe et al. Clin Chem Lab Med. .

Abstract

The declared "war on cancer" aimed to eradicate this disease using our knowledge of cancer cell biology to develop novel therapeutics. One such target of these novel therapies has been the human epidermal growth factor receptor 2 (HER2) gene. Unique in the approach to abolishing function of this gene coded receptor, it was the first target of new monoclonal antibody therapy targeting the extracellular receptor and now also a target of small molecule drugs against the intracellular tyrosine kinase domain. In this instance, it was also one of the first applications of personalized medicine requiring companion diagnostics. In this manuscript, we review the biology and clinical applications of HER2 as a biomarker of disease and as a therapeutic target.

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