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. 2011 Nov 1;21(21):6433-9.
doi: 10.1016/j.bmcl.2011.08.088. Epub 2011 Aug 25.

A Pd-mediated new strategy to functionalized 2-aminochromenes: their in vitro evaluation as potential anti tuberculosis agents

T Ram Reddy  1 , L Srinivasula Reddy, G Rajeshwar Reddy, Venkata Subbaiah Nuthalapati, Y Lingappa, Sandhya Sandra, Ravikumar Kapavarapu, Parimal Misra, Manojit Pal
Affiliations

A Pd-mediated new strategy to functionalized 2-aminochromenes: their in vitro evaluation as potential anti tuberculosis agents

T Ram Reddy et al. Bioorg Med Chem Lett. .

Abstract

A multi component based synthesis involving palladium catalyzed C-C bond forming reaction has been developed as a new strategy to access systematically modified functionalized 2-aminochromenes. This MCR involves the use of bromobenzaldehyde as a key component and is highlighted by generating a new compound library. Many of these compounds showed Mycobacterium tuberculosis H37Rv chorismate mutase inhibiting properties in vitro representing the lead example of chorismate mutase inhibition by heteroarene based compounds.

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