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. 2011;4(4):312-8.
doi: 10.1159/000330710. Epub 2011 Aug 1.

Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

Marianne U Jakobsen  1 , Claus Dethlefsen, Karen M Due, Nadia Slimani, Veronique Chajès, Anne M May, Thorkild I A Sørensen, Jytte Halkjær, Anne Tjønneland, Francoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Birgit Teucher, Rudolf Kaaks, Heiner Boeing, Madlen Schütze, Antonia Trichopoulou, Dimosthenis Zylis, George Makrygiannis, Domenico Palli, Amalia Mattiello, Giovanna Tagliabue, Daphne L van der A, H B Bueno-de-Mesquita, Laudina Rodríguez, Noémie Travier, Esther Molina-Montes, José M Huerta, Aurelio Barricarte, Pilar Amiano, Jonas Manjer, Elisabet Wirfält, Ingegerd Johansson, Göran Hallmans, Kay-Tee Khaw, Nicholas J Wareham, Francesca Crowe, Isabelle Romieu, Elio Riboli, Petra H M Peeters, Kim Overvad
Affiliations

Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

Marianne U Jakobsen et al. Obes Facts. 2011.

Abstract

Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers.

Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression.

Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different.

Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

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