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. 2010 Jul 1;7(1-2):31-35.
doi: 10.1016/j.ddstr.2011.02.004.

Novel Androgen Deprivation Therapy (ADT) in the Treatment of Advanced Prostate Cancer

Jeanny B Aragon-Ching  1 , William L Dahut
Affiliations

Novel Androgen Deprivation Therapy (ADT) in the Treatment of Advanced Prostate Cancer

Jeanny B Aragon-Ching et al. Drug Discov Today Ther Strateg. .

Abstract

Androgen deprivation therapy has been the mainstay of treatment for advanced and metastatic prostate cancer. The use of novel agents targeting the androgen receptor and its signaling pathways offers a promising approach that is both safe and effective. We describe the rationale behind the use of these compounds in clinical development and the existing challenges as to how best to incorporate these new and emerging therapies in the changing treatment paradigm of metastatic prostate cancer.

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References

    1. Jemal A, et al. Cancer Statistics. CA Cancer J Clin. 2010 2010. Epub ahead of print. - PubMed
    1. Pound CR, et al. Natural history of progression after PSA elevation following radical prostatectomy. JAMA. 1999;281(17):1591–1597. - PubMed
    1. Huggins C, Bergenstal DM. Inhibition of human mammary and prostatic cancers by adrenalectomy. Cancer Res. 1952;12(2):134–141. - PubMed
    1. Debes JD, Tindall DJ. Mechanisms of androgen-refractory prostate cancer. N Engl J Med. 2004;351(15):1488–1490. - PubMed
    1. Tannock IF, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med. 2004;351(15):1502–1512. - PubMed

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